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Beilstein J. Org. Chem. 2018, 14, 1222–1228, doi:10.3762/bjoc.14.104
Graphical Abstract
Figure 1: Bioactive pyrazolo[1,5-a]pyrimidinones.
Scheme 1: Synthesis of 5-aminopyrazoles. Reaction conditions: ketonitrile (2.0 mmol, 1.0 equiv), hydrazine (2...
Scheme 2: One-pot synthesis of pyrazolo[1,5-a]pyrimidinones. aReaction conditions: ketonitrile (0.9 mmol, 1.0...
Figure 2: X-ray crystal structure of pyrazolo[1,5-a]pyrimidinone 3m with ellipsoids at 50% probability.